ICU sedation, delirium & recovery
Association Between Vaccination Status and Outcomes in Patients Admitted to the ICU With COVID-19*
Authors' conclusion
Mortality risk remains substantial in vaccinated patients and similar between vaccinated and unvaccinated patients after the onset of critical illness.
Study context
- Population
- Patients admitted to an ICU with COVID-19 (SARS-CoV-2 PCR) in Alberta, Canada, January 2021–July 2022
- Participants
- 3,293 patients
- Exposure
- Unvaccinated vs Fully vaccinated
- Fully vaccinatedn = 743reference
- Partially vaccinatedn = 166
- Unvaccinatedn = 2,384
- Outcome
- All-cause in-hospital mortality (propensity-matched)
Methodological detailspropensity-matched
- Propensity-matched
Main finding
In-hospital mortality
Adjusted odds ratio
1.25
95% CI 0.97–1.61
By group
Unvaccinated vs Fully vaccinated
aOR 1.25 (95% CI 0.97–1.61)
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Fully vaccinated | Unvaccinated | P value |
|---|---|---|---|
| Invasive MV, vasopressor use, ECMOFirst value per group = invasive MV | 78.4% | ||
| Vasopressor use | — not stated in the abstract | 71.1% | |
| ECMO | — not stated in the abstract | 2.1% | |
| Duration of MVUnvaccinated vs Fully vaccinated · longer in unvaccinated · propensity-matched analysis | median 4.7 d | median 7.6 d | P < 0.001 |
| ICU LOSUnvaccinated vs Fully vaccinated · longer in unvaccinated · propensity-matched analysis | median 5.2 d | median 6.6 d | P < 0.001 |
| Duration of MV among vaccinated, by booster (subgroup)≥1 booster vs No booster | P = 0.025 |
— not stated in the abstract
- Invasive mechanical ventilation (MV), vasopressor use, ECMO: Vaccinated 68.2% · vasopressor use 66.6% · ECMO 0.5%
- In-hospital mortality among vaccinated, by booster (subgroup): ≥1 booster 25.5%
- In-hospital mortality among vaccinated, by booster (subgroup): No booster 40.9%
- Duration of MV among vaccinated, by booster (subgroup): ≥1 booster 3.8 d
- Duration of MV among vaccinated, by booster (subgroup): No booster 5.6 d
Invasive MV, vasopressor use, ECMO
- Unvaccinated patients more likely to require invasive MV, vasopressors and ECMO
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association Between Vaccination Status and Outcomes in Patients Admitted to the ICU With COVID-19*. Crit Care Med. Published 16 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →