Cardiac arrest & resuscitation
Association of coronary angiography with ST-elevation and no ST-elevation in patients with refractory ventricular fibrillation – A substudy of the DOuble SEquential External Defibrillation for Refractory Ventricular Fibrillation (DOSE-VF randomized control trial)
Authors' conclusion
We found high rates of angiography/PCI in patients with STE compared to NO-STE, however similar rates of survival. Angiography was an independent predictor of survival.
Study context
- Population
- Adults (≥18 years) with refractory VF/pulseless VT out-of-hospital cardiac arrest (OHCA) randomised in DOSE-VF who survived to hospital admission
- Participants
- 151 adults
- Comparison
- ST-elevation (STE) vs no ST-elevation (NO-STE) on post-arrest ECG
- STEn = 74
- NO-STEn = 77reference
- Primary endpoint
- Proportion of angiography
Primary result
As reported in the abstract
Angiography
P < 0.001
Further findings
PCI
P < 0.001
Survival to discharge
P = 0.15
Predictors of survival (regression)
- Decreased age: OR 0.95, 95% CI 0.92-0.98
- P = 0.001
- Angiography: OR 9.33, 95% CI 3.60-26.94
- P < 0.001
- STE was not a predictor of survival
Angiography/PCI by defibrillation strategy
- Use of angiography/PCI did not differ between defibrillation strategies
Original publication
Association of coronary angiography with ST-elevation and no ST-elevation in patients with refractory ventricular fibrillation – A substudy of the DOuble SEquential External Defibrillation for Refractory Ventricular Fibrillation (DOSE-VF randomized control trial). Resuscitation. Published 4 March 2024. doi:10.
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