Association of the dose of maternal general anaesthesia during Caesarean delivery with 5-minute Apgar scores: a retrospective single centre cohort study
Main finding · 5-min Apgar score <7, per 5-MAC-minute increase in EMAC-AUCResult — go to the resultAdjusted odds ratio 1.10 95% CI 1.05–1.22Authors' conclusion
In this cohort of preterm, late preterm, and term neonates delivered via planned CD or Caesarean hysterectomy, total general anaesthetic dose was statistically associated with the 5-min Apgar score, although the clinical effect was modest.
Study context
- Population
- Neonates born via planned Caesarean delivery under maternal GA, January 2013 to March 2022
- Participants
- 101 neonates
- Exposure
- Total maternal GA dose and 5-min Apgar score <7
- Outcome
- 5-min neonatal Apgar score <7
- Follow-up
- 5 min
Methodological detailssingle centre, multivariable logistic regression
- Single centre
- Multivariable logistic regression
Main finding
As reported in the abstract
5-min Apgar score <7, per 5-MAC-minute increase in EMAC-AUC
Adjusted odds ratio
1.10
95% CI 1.05–1.22
P < 0.001
Per 5-MAC-minute increase in EMAC-AUC
aOR 1.10 (95% CI 1.05–1.22); P < 0.001
Per 5-MAC-minute increase in EMAC-AUC, as printed
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| 5-min Apgar score <7, further adjusted for maternal MAP80AUC | 1.05 (1.00–1.16) | P = 0.177 | |
| 0.512Odds ratio (log scale) |
Original publication
Association of the dose of maternal general anaesthesia during Caesarean delivery with 5-minute Apgar scores: a retrospective single centre cohort study. BJA Open. Published 27 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →