The effect of intravenous ondansetron on maternal spinal-induced hypotension in preeclamptic patients undergoing caesarean delivery: A randomised, controlled clinical trial
Authors' conclusion
The intravenous administration of 4 mg of ondansetron can effectively reduce the incidence of spinal anaesthesia-induced hypotension, and consequently decrease the requirement for phenylephrine in patients with preeclampsia undergoing caesarean delivery.
Study context
- Population
- Preeclamptic patients undergoing caesarean delivery under spinal anaesthesia
- Participants
- 120 patients
- Comparison
- IV ondansetron 4 mg vs saline placebo 10 min before spinal injection
- Primary endpoint
- Incidence of hypotension
Methodological detailsprospective, double-blinded, single-centre
- Prospective
- Double-blinded
- Single-centre
Primary result
As reported in the abstract
Spinal anaesthesia-induced hypotension
C
55
%
O
30%
Mean difference (95% CI)P value
C vs O
25%(8.4–43.9%)
P = 0.0009Relative risk (95% CI)
O vs C
0.55(0.34–0.84)
Original publication
The effect of intravenous ondansetron on maternal spinal-induced hypotension in preeclamptic patients undergoing caesarean delivery: A randomised, controlled clinical trial. Eur J Anaesthesiol. Published 30 April 2026. doi:10.
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