Prevention of spinal anaesthesia-induced hypotension during caesarean section using noninvasive cardiac output monitoring: A randomised clinical trial
Authors' conclusion
The incidence of hypotension may be reduced using estimated continuous CO monitoring, however, no differences were seen in the incidence of nausea or reactive hypertension, nor in umbilical arterial pH levels.
Study context
- Population
- Women undergoing elective caesarean delivery under spinal anaesthesia, Japanese hospital
- Participants
- 200 women
- Comparison
- Estimated continuous CO-guided vasopressor administration vs control
- esCCOn = 103
- Controln = 88reference
- Primary endpoint
- Proportion with hypotension (SBP < 100 mmHg and/or mean BP < 65 mmHg)
- Follow-up
- Between spinal anaesthesia injection and delivery
Methodological detailssingle-centre, simple randomisation, Japanese hospital, 13 May 2020 to 27 April 2022
- Single-centre
- Simple randomisation
- Japanese hospital, 13 May 2020 to 27 April 2022
Primary result
As reported in the abstract
P < 0.001
Secondary outcomes
Delivered phenylephrine dose
P = 0.003
Nausea and vomiting, reactive hypertension (SBP ≥ 140 mmHg), umbilical arterial blood pH
- Did not differ between the groups
Original publication
Prevention of spinal anaesthesia-induced hypotension during caesarean section using noninvasive cardiac output monitoring: A randomised clinical trial. Eur J Anaesthesiol Intensive Care. Published 21 August 2025. doi:10.
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