Norepinephrine or phenylephrine for the prevention of post-spinal hypotension after caesarean section: A double-blinded, randomized, controlled study of fetal heart rate and fetal cardiac output
Authors' conclusion
Prophylactic infusion of comparable doses of phenylephrine or norepinephrine has similar effects on fetal heart rate and cardiac output changes after spinal anesthesia.
Study context
- Population
- Parturients with uncomplicated singleton pregnancies scheduled for elective caesarean section under CSE anaesthesiaparturients recruited
- Participants
- 223 parturients
- Comparison
- Norepinephrine vs Phenylephrine
- Norepinephrinen = 90
- Phenylephrinen = 93reference
Methodological detailsprospective, double-blinded
- Prospective
- Double-blinded
Primary result
As reported in the abstract
Change in fetal heart rate and fetal cardiac output · 3 and 6 min after spinal block
- Effects of norepinephrine and phenylephrine on change in fetal heart rate and fetal cardiac output similar
Further findings
| Outcome | Mean difference (L/min) (95% CI) | P value | |
|---|---|---|---|
| Fetal cardiac output decrease within each group · 6 min after subarachnoid blockNorepinephrine · within-group change; remained within normal range | 0.02 (0–0.04) | P = 0.03 | |
| Fetal cardiac output decrease within each group · 6 min after subarachnoid blockPhenylephrine · within-group change; remained within normal range | 0.02 (0–0.04) | P = 0.02 | |
| −0.0200.020.040.06Difference, L/min (linear scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Norepinephrine or phenylephrine for the prevention of post-spinal hypotension after caesarean section: A double-blinded, randomized, controlled study of fetal heart rate and fetal cardiac output. J Clin Anesth. Published 15 June 2024. doi:10.
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