Comparison of mephentermine and norepinephrine infusions for prevention of post-spinal hypotension during elective caesarean delivery: a randomised, double-blind trial
Authors' conclusion
Prophylactic titrated infusions of both mephentermine and norepinephrine maintained good fetal blood gases during elective caesarean delivery, but mephentermine demonstrated superiority over norepinephrine in this respect.
Study context
- Population
- Mothers with term, uncomplicated, singleton pregnancy undergoing elective caesarean delivery under spinal anaesthesia
- Participants
- 60 mothers
- Comparison
- Mephentermine vs norepinephrine prophylactic titrated infusion
- Primary endpoint
- Umbilical artery pH
Methodological detailsdouble-blind
- Double-blind
Primary result
As reported in the abstract
Mephentermine
7.275
mean · SD 0.061
Norepinephrine
7.244
mean · SD 0.049
P = 0.039
Secondary outcomes
Total infusion volume · significantly higher with mephentermine
P = 0.045
Umbilical artery and venous base excess, venous pH
- Significantly higher in the mephentermine group
Apgar scores, fetal acidosis (umbilical artery pH <7.2), maternal hypotension, hypertension, bradycardia, tachycardia, maternal complications
- Did not differ between the groups
Original publication
Comparison of mephentermine and norepinephrine infusions for prevention of post-spinal hypotension during elective caesarean delivery: a randomised, double-blind trial. Int J Obstet Anesth. Published 9 October 2024. doi:10.
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