Association of early changes in arterial carbon dioxide with acute brain injury in adult patients with extracorporeal membrane oxygenation: A ten-year retrospective study in a German tertiary care hospital
Authors' conclusion
Irrespective of the indication for ECMO, we did not find a significant association between the relative change in PaCO2 early after ECMO initiation and acute brain injury.
Study context
- Population
- Adults requiring extracorporeal membrane oxygenation (ECMO) for circulatory or respiratory failure with a cerebral CT scan available, German tertiary care hospital, January 2011–April 2021
- Participants
- 618 adults
- Exposure
- Venovenous ECMO vs Venoarterial ECMO
- Venovenous ECMOn = 295
- Venoarterial ECMOn = 323reference
- Outcome
- Association of relative change of PaCO2 (RelΔPaCO2) with ICH, IS or a composite of ICH, IS and mortality
Methodological detailssingle-centre, multivariable logistic regression
- Single-centre
- Multivariable logistic regression
Main finding
As reported in the abstract
Association of RelΔPaCO2 with ICH or IS
- No significant association between RelΔPaCO2 and intracranial hemorrhage (ICH) or ischemic stroke (IS)
Observational data: associations, not effects.
Further findings
| Outcome | Venovenous ECMO | Venoarterial ECMO | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| ICH, respiratory vs circulatory failure | 19.0% | 6.8% | 3.683 (1.855–7.309) | P < 0.001 | |
| IS, respiratory vs circulatory failure | 4.7% | 19.2% | 0.360 (0.158–0.820) | P = 0.015 | |
| 0.10.31310Odds ratio (log scale) |
Original publication
Association of early changes in arterial carbon dioxide with acute brain injury in adult patients with extracorporeal membrane oxygenation: A ten-year retrospective study in a German tertiary care hospital. J Crit Care. Published 17 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →