Perioperative medicine & outcomes
Association of Chronotropic Competence With Intraoperative Hypotension and Vasopressor Requirement: A Retrospective Cohort Study
Authors' conclusion
In this surgical cohort, chronotropic competence was neither associated with increased magnitude of hypotension nor with an increase in vasopressor requirements.
Study context
- Population
- Patients who underwent preoperative cardiopulmonary exercise testing before surgery, January 2020–August 2022
- Participants
- 195 patients
- Exposure
- Chronotropic incompetence vs no CI
- CIn = 89
- Outcome
- Time-weighted average of hypotension (MAP <65 mm Hg) and total vasopressor doses (phenylephrine-equivalent, metaraminol, ephedrine, phenylephrine; µg·kg-1·h-1)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Time-weighted average of hypotension
P = 0.197
Observational data: associations, not effects.
Further findings
Phenylephrine-equivalent total doses · no difference
P = 0.139
Metaraminol dose · higher doses with no CI
BH-adjusted P = .034
Resting heart rate · lower in CI
P < 0.001
Peak heart rate · lower in CI
P < 0.001
Peak oxygen consumption · lower in CI
P < 0.001
Oxygen consumption at anaerobic threshold · lower in CI
P = 0.002
| Outcome | P value |
|---|---|
| Ephedrine and phenylephrine dosesEphedrine; no difference | BH-adjusted P = .231 |
| Ephedrine and phenylephrine dosesPhenylephrine; no difference | BH-adjusted P = .763 |
Original publication
Association of Chronotropic Competence With Intraoperative Hypotension and Vasopressor Requirement: A Retrospective Cohort Study. Anesth Analg. Published 1 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →