Perioperative medicine & outcomes
Multimodal prehabilitation before lung resection surgery: a multicentre randomised controlled trial
Authors' conclusion
In high-risk patients undergoing elective lung resection surgery, multimodal prehabilitation, including high-intensity respiratory muscle training to target VE/VCO2, reduced postoperative pulmonary complications and hospital length of stay.
Study context
- Population
- Patients undergoing lung resection at high risk for postoperative pulmonary complications (VE/VCO2 slope ≥33 on cardiopulmonary exercise testing)122 completed the study
- Participants
- 58 vs 64
- Comparison
- Multimodal prehabilitation vs usual care before lung resection
- Multimodal prehabilitationn = 58
- Usual caren = 64reference
- Primary endpoint
- Postoperative pulmonary and cardiovascular complications (pneumonia, atelectasis, respiratory failure necessitating mechanical ventilation, ARDS, prolonged air leak)
Methodological detailsprospective, multicentre
- Prospective
- Multicentre
Primary result
Postoperative pulmonary complications
Odds ratio
2.29
95% CI 1.10–4.77
P = 0.029
Events by treatment group
Multimodal prehabilitation vs Usual care
OR 2.29 (95% CI 1.10–4.77); P = 0.029
As reported in the abstract
Further findings
Hospital LOS
P = 0.038
VE/VCO2 slope after prehabilitation (before vs after)
- Mean (SD) VE/VCO2 slope decreased from 39 (8) to 36 (9); P=0.01
Patient-reported quality of life
- Improved by prehabilitation
Original publication
Multimodal prehabilitation before lung resection surgery: a multicentre randomised controlled trial. Br J Anaesth. Published 14 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →