Perioperative medicine & outcomes
Effect of Multimodal Prehabilitation on Reducing Postoperative Complications and Enhancing Functional Capacity Following Colorectal Cancer Surgery: The PREHAB Randomized Clinical Trial
An erratum to this article was published (JAMA Surg, 1 Jun 2023 ↗)
Primary result · Severe complications (CCI score >20)Result — go to the resultOdds ratio 0.47 95% CI 0.26–0.87- prematurely stopped (COVID-19 pandemic)
- Trial prematurely stopped due to the COVID-19 pandemic
Authors' conclusion
This PREHAB trial demonstrates the benefit of a multimodal prehabilitation program before colorectal cancer surgery as reflected by fewer severe and medical complications postoperatively and an optimized postoperative recovery compared with standard care.
Study context
- Population
- Adults with nonmetastasized colorectal cancer undergoing surgery in teaching hospitals with ERAS programsITT population
- Participants
- 251 adults
- Comparison
- Prehabilitation vs Standard care
- Prehabilitationn = 123
- Standard caren = 128reference
- Primary endpoint
- Comprehensive Complication Index (CCI) score, number of patients with CCI score >20, and 6-minute walking distance
- Follow-up
- 4 weeks postoperatively
Methodological detailsinternational, multicentre, Enrolled June 2017 to December 2020; follow-up completed December 2021
- International
- Multicentre
- Enrolled June 2017 to December 2020; follow-up completed December 2021
Primary result
Severe complications (CCI score >20)
Odds ratio
0.47
95% CI 0.26–0.87
P = 0.02
Events by treatment group
Prehabilitation vs Standard care
OR 0.47 (95% CI 0.26–0.87); P = 0.02
As reported in the abstract
Further findings
| Outcome | Mean difference (m) (95% CI) | P value | |
|---|---|---|---|
| 6-minute walking distance vs baseline · Four weeks after surgeryDid not differ significantly | 15.6 (−1.4 to 32.6) | P = 0.07 | |
| −2002040Difference, m (linear scale) |
Secondary parameters of functional capacity
- Generally favored prehabilitation vs standard care
Safety
| Outcome | Prehabilitation | Standard care | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Medical complications (eg, respiratory) | 15.4% | 27.3% | 0.48 (0.26–0.89) | P = 0.02 | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Effect of Multimodal Prehabilitation on Reducing Postoperative Complications and Enhancing Functional Capacity Following Colorectal Cancer Surgery: The PREHAB Randomized Clinical Trial. JAMA Surg. Published 1 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →