Perioperative medicine & outcomes
Nationwide Implementation of Multimodal Prehabilitation and Complications After Colorectal Cancer Surgery
Main finding · Overall complicationsResult — go to the resultOdds ratio 0.71 95% CI 0.60–0.84Authors' conclusion
Results of this cohort study show that implementation of a uniform multimodal prehabilitation program for unselected patients undergoing colorectal cancer surgery was associated with reduced complication rates and length of hospital stay across all age and ASA score subgroups.
Study context
- Population
- Adults undergoing elective colorectal cancer resection, 18 hospitals in the Netherlandspropensity-matched
- Participants
- 2,384 adults
- Exposure
- Multimodal prehabilitation vs historical controls
- Prehabilitationn = 1,192
- Controln = 1,192reference
- Outcome
- Overall complications
Methodological detailspropensity score matching, historical controls, multicenter, nationwide implementation
- Propensity score matching
- Historical controls
- Multicenter
- Nationwide implementation
Main finding
As reported in the abstract
Odds ratio
0.71
95% CI 0.60–0.84
Events by group
Prehabilitation vs Control
OR 0.71 (95% CI 0.60–0.84)
Observational data: associations, not effects.
Further findings
| Outcome | Prehabilitation | Control | OR (95% CI) | |
|---|---|---|---|---|
| Medical complicationsPropensity-matched cohort | 15.4% | 24.6% | 0.56 (0.46–0.69) | |
| Surgical complicationsPropensity-matched cohort | 21.4% | 24.9% | 0.82 (0.68–1.00) | |
| 0.512Odds ratio (log scale) |
- Medical complications: 182 of 1181 vs 290 of 1181
- Surgical complications: 253 of 1181 vs 294 of 1181
Readmission and ICU admission
- Rates of readmission and ICU admission reduced with prehabilitation
Complications by age and American Society of Anesthesiologists (ASA) score (subgroup)
- Reduction in complication rates with prehabilitation irrespective of age and ASA score
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Nationwide Implementation of Multimodal Prehabilitation and Complications After Colorectal Cancer Surgery. JAMA Surg. Published 1 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →