Neuroanesthesia & neurocritical care
Association of early in-hospital endotracheal intubation with clinical outcomes in patients with traumatic coma: a multicenter observational study
Authors' conclusion
Hospital-level analysis found that endotracheal intubation in the resuscitation area in patients with a GCS score < 8 following trauma was associated with better neurological outcomes after adjusting for patient characteristics and injury severity.
Study context
- Population
- Adults (≥ 18 years) with trauma and Glasgow coma scale (GCS) < 8 on hospital arrival, Japan Trauma Data Bank, January 2019–December 2023
- Participants
- 11,927 adults · 96 hospitals
- Exposure
- Endotracheal intubation in the resuscitation area vs no intubation
- Outcome
- Favorable neurological outcomes (correlation with hospital-level intubation rates)
Methodological detailsmulticentre registry, hierarchical regression, hospital-level analysis
- Multicentre registry
- Hierarchical regression
- Hospital-level analysis
Main finding
As reported in the abstract
Favorable neurological outcomes vs hospital-level intubation rate
Higher hospital-level intubation rates correlated with favorable neurological outcomes (Pearson r), p = 0.015
0.247
Observational data: associations, not effects.
Further findings
Overall survival
- Hospital-level intubation rates not correlated with overall survival
Intubation in resuscitation area
- Proportion intubated in resuscitation area
- 67.9%
- Range of hospital-level intubation rates
- 0% to 93.5%
Original publication
Association of early in-hospital endotracheal intubation with clinical outcomes in patients with traumatic coma: a multicenter observational study. Crit Care. Published 9 July 2025. doi:10.
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