Cardiac arrest & resuscitation
Association of hyperfibrinolysis with poor prognosis in refractory circulatory arrest: implications for extracorporeal cardiopulmonary resuscitation
Authors' conclusion
Hyperfibrinolysis was common in patients with refractory cardiac arrest, and was associated with poor prognosis.
Study context
- Population
- Adults with ongoing refractory out-of-hospital cardiac arrest (OHCA) presenting to ICU for extracorporeal cardiopulmonary resuscitation (eCPR) evaluation
- Participants
- 57 adults
- Exposure
- Hyperfibrinolysis vs no hyperfibrinolysis
- Poor outcomen = 28
- Good outcomen = 14reference
- Outcome
- Hyperfibrinolysis (maximum lysis ≥15%) on rotational thromboelastometry (ROTEM)
Main finding
As reported in the abstract
Hyperfibrinolysis (maximum lysis ≥15%)
P < 0.001
Observational data: associations, not effects.
Further findings
Prevalence of hyperfibrinolysis (maximum lysis ≥15%)
- Hyperfibrinolysis present, n (%)
- 36 (63%)
Hyperfibrinolysis and resuscitation parameters
- Hyperfibrinolysis associated with higher serum lactate, lower arterial blood pH and increased low-flow intervals
EXTEM A5 to lactate ratio for detecting hyperfibrinolysis
- AUC
- 0.89 (95% CI 0.8-1)
Original publication
Association of hyperfibrinolysis with poor prognosis in refractory circulatory arrest: implications for extracorporeal cardiopulmonary resuscitation. Br J Anaesth. Published 17 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →