Hemodynamics, fluids & transfusion
Association of Hypocalcemia and Mean Arterial Pressure With Patient Outcome in ICU
Main finding · ICU mortality by iCaResult — go to the resultOdds ratio 0.17 95% CI 0.04–0.79Authors' conclusion
In this retrospective study on nonhypercalcemia patients, iCa of the first 24 hours after admission was independently associated with ICU mortality, which was potentially mediated by TWA-MAP and blood pressure reactivity (TWA-MAP/NE). iCa was also positively associated with TWA-MAP, while no general relationship was found between iCa and TWA-MAP/NE.
Study context
- Population
- Nonhypercalcemia adult ICU patients, Peking Union Medical College Hospital, January 2013 to December 20224,091 in multivariate analysis
- Participants
- 4,947 patients
- Exposure
- Hypocalcemia vs no hypocalcemia
- Hypocalcemian = 2,160
- Outcome
- ICU mortality by iCa
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Odds ratio
0.17
95% CI 0.04–0.79
P < 0.05
Observational data: associations, not effects.
Further findings
Mediation of ionized calcium (iCa)–ICU mortality association · first 24 hr
- Proportion mediated by TWA-MAP-0
- 4.55% (95% CI, 0.16-17%; p < 0.05)
- Proportion mediated by TWA-MAP-0/NE
- 2.6% (95% CI, 0.02-11%; p < 0.05)
Correlation of iCa with TWA-MAP-0 and TWA-MAP-0/NE
- TWA-MAP-0 vs iCa, Spearman ρ (p < 0.01)
- 0.17
- TWA-MAP-0/NE vs iCa, Spearman ρ (p < 0.01); no significant association
- −0.07
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →