ICU sedation, delirium & recovery
Association of low-dose ketamine with hallucinations in critically ill patients: a target trial emulation
Main finding · HallucinationsResult — go to the resultOdds ratio 6.46 95% CI 5.17–8.07Authors' conclusion
In ICU patients, low-dose ketamine was strongly associated with an increased risk of hallucinations.
Study context
- Population
- Critically ill intensive care unit (ICU) patients, university affiliated ICU in Melbourne, Australia, June 2016 to April 2021
- Participants
- 7,514 patients
- Exposure
- Low-dose ketamine vs no ketamine exposure
- Low-dose ketaminen = 625
- Outcome
- Hallucinations
- Follow-up
- Within 30 days of ICU admission
Methodological detailstarget trial emulation, marginal structural models, parametric g-formulas, single-centre
- Target trial emulation
- Marginal structural models
- Parametric g-formulas
- Single-centre
Main finding
As reported in the abstract
Odds ratio
6.46
95% CI 5.17–8.07
P < 0.001
By group
Low-dose ketamine vs Unexposed
OR 6.46 (95% CI 5.17–8.07); P < 0.001
Observational data: associations, not effects.
Further findings
Time to first hallucination episode
P < 0.001
Original publication
Association of low-dose ketamine with hallucinations in critically ill patients: a target trial emulation. Intensive Care Med. Published 5 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →