Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study
Main findingResult — go to the resultHazard ratio 0.70 95% CI 0.61–0.79Authors' conclusion
Magnesium sulfate use was associated with lower mortality in critically ill patients with sepsis.
Study context
- Population
- Adult critically ill patients with sepsis (MIMIC-IV database)6,052 matched
- Participants
- 10,999 patients
- Exposure
- Magnesium sulfate use vs no use during ICU stay
- Magnesium sulfate usen = 3,026
- No usen = 3,026reference
- Outcome
- 28-day all-cause mortality
- Follow-up
- 28 days
Methodological detailspropensity-score matched (1:1), MIMIC-IV database, multivariable analyses
- Propensity-score matched (1:1)
- MIMIC-IV database
- Multivariable analyses
Main finding
As reported in the abstract
Hazard ratio
0.70
95% CI 0.61–0.79
P < 0.001
Events by group
Magnesium sulfate use vs No use
HR 0.70 (95% CI 0.61–0.79); P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| ICU mortality | 0.52 (0.42–0.64) | P < 0.001 | |
| In-hospital mortality | 0.65 (0.55–0.77) | P < 0.001 | |
| RRT | 0.67 (0.52–0.87) | P = 0.002 | |
| 0.512Odds ratio (log scale) |
28-day all-cause mortality, hypomagnesaemia (subgroup)
- Lower mortality with magnesium sulfate use, hypomagnesaemia: HR (95% CI), P
- 0.64 (0.45-0.93), P=0.020
- Propensity score matching (PSM) analysis
28-day all-cause mortality, normomagnesaemia (subgroup)
- Lower mortality with magnesium sulfate use, normomagnesaemia: HR (95% CI), P
- 0.70 (0.61-0.80), P<0.001
- PSM analysis
28-day all-cause mortality, entire cohort (sensitivity analysis)
- Lower 28-day all-cause mortality in the entire cohort: HR (95% CI), P
- 0.62 (0.56-0.69), P<0.001
- Sensitivity analysis
Original publication
Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study. Br J Anaesth. Published 7 September 2023. doi:10.
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