Perioperative medicine & outcomes
Association of Obstructive Sleep Apnea With Postoperative Delirium in Procedures of Moderate-to-High Complexity: A Hospital-Registry Study
Authors' conclusion
Compared to non-OSA patients, a history of OSA is associated with a higher risk after high-complexity procedures such as cardiac or thoracic surgery but not after procedures of moderate complexity.
Study context
- Population
- Hospitalized patients ≥60 years undergoing GA or procedural sedation for procedures of moderate-to-high complexity, 2009–2020, tertiary health care network in Massachusetts
- Participants
- 46,352 patients
- Exposure
- Obstructive sleep apnea (OSA) vs no OSA
- Outcome
- Delirium
- Follow-up
- Within 7 days after the procedure
Methodological detailshospital registry, multivariable logistic regression, effect modification analysis
- Hospital registry
- Multivariable logistic regression
- Effect modification analysis
Main finding
Postprocedural delirium, overall cohort
Adjusted odds ratio
1.06
95% CI 0.94–1.20
P = 0.35
Events by group
OSA vs Non-OSA
aOR 1.06 (95% CI 0.94–1.20); P = 0.35
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| Delirium after cardiac surgery (high-complexity subgroup)P value for interaction = .005 | 1.33 (1.08–1.64) | P = 0.007 | |
| Delirium after thoracic surgery (high-complexity subgroup)P value for interaction = .009 | 1.89 (1.19–3.00) | P = 0.007 | |
| Delirium after general surgery (moderate-complexity subgroup) | 0.86 (0.55–1.35) | P = 0.52 | |
| 0.20.5125Adjusted odds ratio (log scale) |
Original publication
Association of Obstructive Sleep Apnea With Postoperative Delirium in Procedures of Moderate-to-High Complexity: A Hospital-Registry Study. Anesth Analg. Published 30 March 2023. doi:10.
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