Haemodynamics, fluids & transfusion

Association of preoperative hemoglobin levels with intraoperative hypotension: a retrospective cohort study

Can J AnaesthPublished retrospective cohort study

Authors' conclusion

Lower preoperative hemoglobin levels were significantly associated with an increased risk of IOH and longer postoperative length of hospital stay. These findings highlight the potential value of incorporating hemoglobin level assessments into IOH risk stratification and may help improve patient outcomes.

Study context

Population
Patients aged ≥ 18 yr who underwent general anesthesia between 2019 and 2023
Participants
2,060 patients
Exposure
Preoperative hemoglobin levels and intraoperative hypotension
Outcome
IOH at MBP < 65 and < 45 mm Hg

Main finding

As reported in the abstract

No significant association between preoperative hemoglobin levels and intraoperative hypotension (IOH) risk at mean blood pressure (MBP) < 65 mm Hg
P = 0.13
No significant association between preoperative hemoglobin levels and IOH risk at MBP < 45 mm Hg
P = 0.12

Observational data: associations, not effects.

Further findings

IOH at MBP < 60 mm Hg

Lower preoperative hemoglobin levels associated with significantly higher risk of IOH
P = 0.03

IOH at MBP < 55 mm Hg and < 50 mm Hg

Similar trends at < 55 mm Hg
0.02
Similar trends at < 50 mm Hg
0.03

IOH episodes and odds ratios

Lower hemoglobin levels associated with more frequent IOH episodes and higher odds ratios

Postoperative length of hospital stay

Significant association between lower preoperative hemoglobin levels and a longer postoperative length of hospital stay
  • Generalized additive model

Original publication

Association of preoperative hemoglobin levels with intraoperative hypotension: a retrospective cohort study. Can J Anaesth. Published 12 October 2026. doi:10.1007/s12630-026-03207-2

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