Perioperative medicine & outcomes
Association of preoperative to postoperative change in cerebrospinal fluid fibrinogen with postoperative delirium
Authors' conclusion
Our preliminary findings support the hypothesis that fibrinogen enters the brain via blood-brain barrier disruption, promoting neuroinflammation and neuronal injury. However, we did not observe an association between cerebrospinal fluid fibrinogen and peak delirium severity in this limited cohort.
Study context
- Population
- Patients aged >21 yr undergoing aortic aneurysm repair
- Participants
- 24 vs 13
- Comparison
- Preoperative vs postoperative cerebrospinal fluid (CSF) fibrinogen
- Before surgeryn = 24reference
- After surgeryn = 13
- Primary endpoint
- Perioperative change in CSF fibrinogen
Primary result
As reported in the abstract
- CSF fibrinogen increased after surgery
- P<0.001
Further findings
Association of CSF fibrinogen increase with CSF/plasma albumin ratio
- β
- 1.09 (95% CI 0.47-1.71, P=0.004)
Peak change in CSF fibrinogen and change in CSF IL-10 and IL-12p70
- Peak change in CSF fibrinogen associated with change in CSF IL-10 and IL-12p70
Peak change in CSF fibrinogen and change in CSF total tau
- β
- 0.47 (95% CI 0.24-0.71, P=0.002)
Peak change in CSF fibrinogen and postoperative delirium severity (Delirium Rating Scale-Revised-98)
- IRR
- 1.20 (95% CI 0.66-2.17, P=0.540)
- No association observed
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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