Association of Prophylactic Antibiotics With Early Infectious Complications in Children With Cancer Undergoing Central Venous Access Device Placement
Main finding · Early infectious complications, overallResult — go to the resultOdds ratio 0.55 95% CI 0.39–0.79Authors' conclusion
Prophylactic antibiotics are associated with reduced early infectious complications after central VAD placement overall.
Study context
- Population
- Children with cancer undergoing central venous access device (VAD) placement, Pediatric Health Information System database, 2017–20216,058 ports · 3,158 tunneled lines
- Participants
- 9,216 children
- Exposure
- Prophylactic antibiotics vs none at central VAD placement
- Outcome
- Early infectious complications:
- Surgical site infections
- Central line-associated bloodstream infections
- Bacteremia
Methodological detailsmultivariable logistic regression, Pediatric Health Information System database
- Multivariable logistic regression
- Pediatric Health Information System database
Main finding
Early infectious complications, overall
Odds ratio
0.55
95% CI 0.39–0.79
P < 0.001
By group
Prophylactic antibiotics vs No prophylactic antibiotics
OR 0.55 (95% CI 0.39–0.79); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Early infectious complications, tunneled lines (subgroup) | 0.59 (0.41–0.84) | |
| Early infectious complications, ports (subgroup) | 3.01 (0.66–13.78) | |
| 0.050.21520Odds ratio (log scale) |
Factors associated with early infection (multivariate analysis)
- Prophylactic antibiotics, OR
- 0.67 (95% CI 0.45-0.97)
- Solid tumors, OR
- 0.38 (95% CI 0.22-0.64)
- Tunneled lines, OR
- 20.78 (95% CI 9.83-43.93)
- Acute myelogenous leukemia, OR
- 2.37 (95% CI 1.58-3.57)
Original publication
Association of Prophylactic Antibiotics With Early Infectious Complications in Children With Cancer Undergoing Central Venous Access Device Placement. Ann Surg. Published 23 October 2023. doi:10.
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