Perioperative medicine & outcomes
Postoperative Day 2 C-reactive Protein Identifies Patients at Low Risk of Anastomotic Leakage After Colon Cancer Resection
Study context
- Population
- Patients undergoing elective colon cancer resection with primary anastomosistest cohort 401 · validation cohort 213
- Participants
- 401 vs 213
- Comparison
- POD2 C-reactive protein (CRP) <100 mg/L for excluding anastomotic leakage (AL) (Clavien-Dindo grade ≥3); in patients with POD2 CRP ≥100 mg/L, POD3/POD2 ratio <1
- Testn = 401
- Validationn = 213
- Outcome
- AL (Clavien-Dindo grade ≥3)
Performance
As reported in the abstract
Further findings
POD2 CRP <100 mg/L: AL and NPV test patients with POD2 CRP <100 mg/L 60% · validation patients with POD2 CRP <100 mg/L 46%
AL among patients with POD2 CRP <100 mg/L
NPV
AL among patients with POD2 CRP ≥100 mg/L
POD3/POD2 ratio <1 among patients with POD2 CRP ≥100 mg/L (combined cohort)
- NPV, minimally invasive surgery
- 98.9%
- NPV, open surgery
- 97.9%
- Two-step strategy: patients who could be discharged by POD2 or 3 with AL risk near 1%
- nearly 90%
- Combined cohort
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Postoperative Day 2 C-reactive Protein Identifies Patients at Low Risk of Anastomotic Leakage After Colon Cancer Resection. Ann Surg. Published 9 October 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →