Perioperative medicine & outcomes
Risk Factor–Targeted Perioperative Care Reduces Anastomotic Leakage After Colorectal Surgery: The DoubleCheck Study
Authors' conclusion
The DoubleCheck study showed that optimization of modifiable risk factors reduced CAL in colorectal surgery.
Study context
- Population
- Patients undergoing colorectal surgery with anastomosis
- Participants
- 902 vs 1,572
- Comparison
- DoubleCheck vs LekCheck
- DoubleCheckn = 902
- LekCheckn = 1,572reference
- Outcome
- Occurrence of intraoperative risk factors (anemia, hyperglycemia, hypothermia, incorrect antibiotic timing, vasopressors, epidural analgesia) just before anastomosis creation
Methodological detailsinternational, open-labeled, September 2021 to December 2023
- International
- Open-labeled
- September 2021 to December 2023
Main finding
As reported in the abstract
Number of risk factors
DoubleCheck
1.63
mean
LekCheck
1.84
mean
P < 0.001
Secondary outcomes
Colorectal anastomotic leakage (CAL) — DoubleCheck vs LekCheck · significantly lower in DoubleCheck
P = 0.039
Colorectal anastomotic leakage (CAL)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Enhanced care bundle | 1.521 (1.01–2.29) | P = 0.045 | |
| 0.512Odds ratio (log scale) |
- Colorectal anastomotic leakage (CAL): CAL reduction associated with bundle, multivariate regression
Mortality
- Mortality rate did not differ significantly (1.3% vs 0.8%, P =0.237)
Original publication
Risk Factor–Targeted Perioperative Care Reduces Anastomotic Leakage After Colorectal Surgery: The DoubleCheck Study. Ann Surg. Published 11 July 2024. doi:10.
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