Perioperative medicine & outcomes
A multimodal prehabilitation class for Enhanced Recovery After Surgery: a pragmatic randomised type 1 hybrid effectiveness-implementation trial
Authors' conclusion
A pragmatic prehabilitation programme did not influence length of hospital stay (underpowered because of early trial termination), but did reduce preoperative protein inadequacy (implementation outcome) and improve early functional recovery (secondary outcome).
Study context
- Population
- Adults with colorectal disease requiring elective primary resection, single centretrial ended prematurely
- Participants
- 110 adults
- Comparison
- Multimodal prehabilitation class within Enhanced Recovery After Surgery (ERAS) pathway vs standard care
- Primary endpoint
- LOS
Methodological detailspragmatic, type 1 hybrid effectiveness-implementation, single-centre, ended prematurely, Mean prehabilitation duration 17.2 (SD 5.5) days
- Pragmatic
- Type 1 hybrid effectiveness-implementation
- Single-centre
- Ended prematurely
- Mean prehabilitation duration 17.2 (SD 5.5) days
Primary result
As reported in the abstract
- LOS not different between groups
- Underpowered because of early trial termination
Secondary outcomes
| Outcome | Prevalence ratio (95% CI) | |
|---|---|---|
| Preoperative protein inadequacy (implementation outcome) | 0.59 (0.36–0.82) | |
| 0.20.5125Prevalence ratio (log scale) |
| Outcome | Mean difference (m) (95% CI) |
|---|---|
| 6-min walking distance (6MWD) · 6 weeks post-surgery | +38 (9–67) |
Preoperative median step count (implementation outcome)
- Did not differ between groups
Original publication
A multimodal prehabilitation class for Enhanced Recovery After Surgery: a pragmatic randomised type 1 hybrid effectiveness-implementation trial. Br J Anaesth. Published 7 April 2025. doi:10.
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