Perioperative medicine & outcomes
Prehabilitation With Exercise and Nutrition to Reduce Morbidity of Major Hepatectomy in Patients With Sarcopenia: The PREHEP Randomized Clinical Trial
Primary result · Overall morbidityResult — go to the resultOdds ratio 0.15 95% CI 0.04–0.55Authors' conclusion
Results of this randomized clinical trial reveal that a 6-week structured prehabilitation program significantly reduced postoperative morbidity in patients with sarcopenia undergoing major liver resection.
Study context
- Population
- Adults with radiologically and functionally confirmed sarcopenia scheduled for major liver resection requiring future liver remnant hypertrophy, tertiary hepatobiliary referral centre in Italy60 analysed
- Participants
- 70 adults
- Comparison
- 6-week multimodal prehabilitation vs standard care
- Prehabilitationn = 30
- Standard caren = 30reference
- Primary endpoint
- Postoperative morbidity (Clavien-Dindo classification)
- Follow-up
- 90 days
Methodological detailssingle-centre, open-label
- Single-centre
- Open-label
Primary result
Overall morbidity
Odds ratio
0.15
95% CI 0.04–0.55
P = 0.004
Events by treatment group
Prehabilitation vs Standard care
OR 0.15 (95% CI 0.04–0.55); P = 0.004
As reported in the abstract
- Absolute risk reduction
- 36.7%
- NNT
- 3
Further findings
Major complications
- All major complications occurred in the control group
- 6 of 30 [20%]
- Effect size d
- 0.40
- P
- P = 0.02
Muscle mass and strength
- Improved significantly only in the prehabilitation arm
Original publication
Prehabilitation With Exercise and Nutrition to Reduce Morbidity of Major Hepatectomy in Patients With Sarcopenia: The PREHEP Randomized Clinical Trial. JAMA Surg. Published 1 October 2025. doi:10.
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