Association of Sepsis Survivor Subtypes With Long-Term Mortality and Disability After Discharge: A Retrospective Cohort Study
Authors' conclusion
Sepsis survivor subtypes that are readily identifiable at hospital discharge are significantly associated with mortality at 3 months, and patient-important outcomes through 12 months.
Study context
- Population
- Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis (CLOVERS) trial participants (US, sepsis-induced hypotension) alive on day 28 with nonmissing outcome and subtype-defining dataof 1563 enrolled
- Participants
- 1,368 participants
- Exposure
- Five sepsis survivor subtypes assigned at discharge, vs low-risk subtype
- Outcome
- Mortality
- Follow-up
- 3 months
Methodological detailssecondary use of multisite trial cohort (CLOVERS)
- Secondary use of multisite trial cohort (CLOVERS)
Main finding
As reported in the abstract
3-month mortality
Odds ratio
11.1
P < 0.001
Low functional status
Odds ratio
9.7
P < 0.001
Unhealthy baseline with severe disease
- Overall 3-month mortality
- 13.1%
- Mortality range across subtypes
- 5.1-45.5%
Observational data: associations, not effects.
Secondary outcomes
EuroQol 5D five level score and limitations in activities of daily living · 6 and 12 months
- Subtype a significant predictor
Readmission
- Subtype not a significant predictor
Original publication
Association of Sepsis Survivor Subtypes With Long-Term Mortality and Disability After Discharge: A Retrospective Cohort Study. Crit Care Med. Published 13 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →