Association of Timely Antibiotics and Fluid Resuscitation With Increased Discharge to Home After Sepsis
Authors' conclusion
Our results show that in this multihospital cohort, timely antibiotic delivery and fluid resuscitation were associated with increased discharge to home after sepsis.
Study context
- Population
- Adults hospitalised for confirmed community-onset sepsis at 67 hospitals in the Michigan HMS-Sepsis initiative, 2022–2025
- Participants
- 38,568 adults · 67 hospitals
- Exposure
- Timely vs not timely antibiotic delivery and fluid resuscitation
- Outcome
- Discharge to home
Methodological detailsmulticentre, multivariable-adjusted
- Multicentre
- Multivariable-adjusted
Main finding
As reported in the abstract
Absolute percentage point increase, absolute percentage point (95% CI)
Timely antibiotics
3.0(2.0–4.0)
Timely fluid resuscitation
1.1(0.2–2.1)
- Discharged to home, whole cohort
- 20,685 (53.6%)
Observational data: associations, not effects.
Further findings
Other discharge dispositions, whole cohort
- Died in hospital or discharged to hospice
- 7,942 (20.6%)
- Discharged to postacute care facility
- 9,941 (25.8%)
Delivery of timely care among eligible patients
- Timely antibiotics among 35,025 eligible
- 26,357 (75.3%)
- Fluid resuscitation among 27,393 eligible
- 13,561 (49.5%)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association of Timely Antibiotics and Fluid Resuscitation With Increased Discharge to Home After Sepsis. Chest. Published 13 March 2026. doi:10.
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