Association of Trauma Molecular Endotypes With Differential Response to Transfusion Resuscitation Strategies
Authors' conclusion
Results of this secondary analysis suggest that endotypes derived from plasma biomarkers in trauma patients at hospital arrival were associated with a differential response to 1:1:1 vs 1:1:2 resuscitation strategies in trauma patients with severe injury.
Study context
- Population
- Severely injured patients with hemorrhagic shock from 12 North American trauma centers in the PROPPR trial with complete plasma biomarker dataof 680 PROPPR participants
- Participants
- 478 participants
- Comparison
- Trauma endotypes and their interaction with 1:1:1 vs 1:1:2 resuscitation
- TE-1n = 270
- TE-2n = 208reference
- Primary endpoint
- 30-day mortality by endotype and differential treatment response (endotype × treatment interaction), adjusted RR regression
- Follow-up
- 30 days
Methodological detailsK-means clustering, multicentre
- K-means clustering
- Multicentre
Primary result
As reported in the abstract
30-day mortality by endotype and transfusion strategy (subgroup)
TE-1 mortality with 1:1:2
28.6%
TE-1 mortality with 1:1:1
32.6%
TE-2 mortality with 1:1:2
24.5%
TE-2 mortality with 1:1:1
7.3%
Original publication
Association of Trauma Molecular Endotypes With Differential Response to Transfusion Resuscitation Strategies. JAMA Surg. Published 1 July 2023. doi:10.
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