Traumatic Inflammatory—Coagulation Coactivation Occurs Early After Injury and Impacts Mortality
Authors' conclusion
These findings demonstrate that coagulation and inflammation are coactivated early after severe injury and are associated with poor outcomes.
Study context
- Population
- Severely injured patients at 12 level 1 trauma centers with complete data for 48 coagulation and inflammatory biomarkers from initial ED blood drawsof 680 in PROPPR
- Participants
- 286 participants
- Primary endpoint
- 30-day mortality in relation to inflammatory and coagulation biomarker phenotypes
- Follow-up
- 30 days
Methodological detailsprincipal component analysis, LASSO regression
- Principal component analysis
- LASSO regression
Primary result
As reported in the abstract
Independent predictors of 30-day mortality
- 30-day mortality
- 24.4% (n = 70)
- Coagulopathy phenotype 1 associated with mortality
- p = 0.0002
- Mixed inflammatory phenotype 3 associated with mortality
- p = 0.0684
Further findings
Biomarker phenotypes (principal component analysis (PCA))
- Phenotypes identified, collectively explaining 83% of pathophysiologic variability
- 14
- Top six: coagulopathy, two mixed inflammatory, platelet, von Willebrand Factor (vWF), thromboelastography phenotypes
Original publication
Traumatic Inflammatory—Coagulation Coactivation Occurs Early After Injury and Impacts Mortality. Crit Care Med. Published 28 May 2026. doi:10.
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