Association of Trauma With Long-Term Risk of Death and Immune-Mediated or Cancer Disease in Same-Sex Twins
Main finding · Composite of death or immune-mediated or cancer diseaseResult — go to the resultHazard ratio 1.33 95% CI 1.19–1.49Authors' conclusion
In this study, twins exposed to moderate to severe trauma had significantly increased risk of death or immune-mediated or cancer disease several years after trauma compared with their co-twins.
Study context
- Population
- Same-sex twin pairs in the Danish Twin Registry and Danish National Patient Registry, 1994 to 2018, both twins alive 6 months after trauma
- Participants
- 3,776 twin pairs
- Exposure
- Twin exposed to moderate to severe trauma vs unexposed co-twin
- Outcome
- Composite of death or 1 of 24 predefined immune-mediated or cancer diseases
Methodological detailsregistry-based
- Registry-based
Main finding
As reported in the abstract
Composite of death or immune-mediated or cancer disease
Hazard ratio
1.33
95% CI 1.19–1.49
Events by group
Trauma vs Co-twin
HR 1.33 (95% CI 1.19–1.49)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Death (separate outcome) | 1.91 (1.68–2.18) | |
| Immune-mediated or cancer disease (separate outcome) | 1.28 (1.14–1.44) | |
| 0.512Hazard ratio (log scale) |
Original publication
Association of Trauma With Long-Term Risk of Death and Immune-Mediated or Cancer Disease in Same-Sex Twins. JAMA Surg. Published 1 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →