Neuroanesthesia & neurocritical care
Influence of multiple trauma on the effect of transfusion strategies in patients with traumatic brain injury: a sub-study of the HEMOTION trial
Authors' conclusion
Multiple trauma status was not associated with the effect of liberal vs. restrictive transfusion strategies on the GOS-E.
Study context
- Population
- Moderate-to-severe traumatic brain injury (TBI), with multiple trauma defined as extracranial injury with ISS > 15, emergency extracranial surgery, or spinal injury with neurological deficit
- Participants
- 742 participants
- Comparison
- Liberal vs restrictive transfusion strategy, by multiple trauma status
- Primary endpoint
- Glasgow Outcome Scale Extended (GOS-E)
- Follow-up
- 6-month
Methodological detailssubgroup analysis, sliding dichotomy, hierarchical Poisson regression
- Subgroup analysis
- Sliding dichotomy
- Hierarchical Poisson regression
Primary result
As reported in the abstract
Unfavourable GOS-E outcome by multiple trauma subgroup
Liberal vs RestrictiveAdjusted relative risk (95% CI)
ISS > 15
0.87(0.71–1.07)
Emergency extracranial surgery
0.79(0.59–1.05)
Spinal cord injury
0.99(0.42–2.33)
Secondary outcomes
Interaction, emergency extracranial surgery (sensitivity analyses)
- P-interaction, proportional odds analysis
- 0.02
- P-interaction, classical dichotomy
- 0.05
- Potential interaction
FIM, EQ-5D-5L and Qolibri scores
- Liberal strategy associated with better scores for definitions 1 and 2, but not 3, with no consistent interaction
Mortality and PHQ-9
- Did not differ
Original publication
Influence of multiple trauma on the effect of transfusion strategies in patients with traumatic brain injury: a sub-study of the HEMOTION trial. Intensive Care Med. Published 3 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →