Neuroanaesthesia & neurocritical care
Liberal or Restrictive Transfusion Strategy in Patients with Traumatic Brain Injury
Primary resultResult — go to the resultAdjusted absolute difference 5.4 percentage points 95% CI −2.9 to 13.7Authors' conclusion
In critically ill patients with traumatic brain injury and anemia, a liberal transfusion strategy did not reduce the risk of an unfavorable neurologic outcome at 6 months.
Study context
- Population
- Adults with moderate or severe TBI and anemia, critically ill722 analysed for primary outcome
- Participants
- 742 adults
- Comparison
- Liberal vs restrictive RBC transfusion strategy
- Liberal strategyn = 371
- Restrictive strategyn = 371reference
- Primary endpoint
- Unfavorable outcome on Glasgow Outcome Scale-Extended (sliding dichotomy based on baseline prognosis)
- Follow-up
- 6 months
Primary result
As reported in the abstract
Adjusted absolute difference
5.4 percentage points
95% CI −2.9 to 13.7
Events by treatment group
Restrictive strategy vs Liberal strategy
adjusted absolute difference 5.4 percentage points (95% CI −2.9 to 13.7)
Secondary outcomes
Median hemoglobin level in ICU
Functional independence and quality of life (survivors) · 6 months
- Liberal strategy associated with higher scores on some but not all scales
Mortality and depression · 6 months
- No association with transfusion strategy
Safety
Venous thromboembolic events
ARDS
Original publication
Liberal or Restrictive Transfusion Strategy in Patients with Traumatic Brain Injury. N Engl J Med. Published 13 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →