Neuroanesthesia & neurocritical care
Efficacy of restrictive versus liberal transfusion strategies in patients with traumatic brain injury: a systematic review and meta-analysis of randomized controlled trials
Pooled resultResult — go to the resultRelative risk 1.00 95% CI 0.80–1.24Authors' conclusion
In patients with TBI, a restrictive transfusion strategy did not reduce the risk of mortality or unfavorable neurological outcome compared with a liberal transfusion strategy.
Study context
- Population
- Critically ill adults with moderate to severe traumatic brain injury (TBI)
- Participants
- 1,528 adults · 5 RCTs
- Comparison
- Restrictive vs liberal RBC transfusion strategy
- Outcome
- Mortality
Pooled result
As reported in the abstract
Relative risk
1.00
95% CI 0.80–1.24
Restrictive vs Liberal
RR 1.00 (95% CI 0.80–1.24)
Further pooled results
| Outcome | RR (95% CI) | |
|---|---|---|
| Unfavorable neurological outcome (GOS < 4 or GOSE < 6) · 6 monthsI2 = 47% | 1.06 (0.94–1.20) | |
| 0.512Relative risk (log scale) |
| Outcome | MD (units) (95% CI) | |
|---|---|---|
| Units of pRBCs transfusedI2 = 63% | −2.62 (−3.33 to −1.90) | |
| −4−202Difference, units (linear scale) |
Original publication
Efficacy of restrictive versus liberal transfusion strategies in patients with traumatic brain injury: a systematic review and meta-analysis of randomized controlled trials. Ann Intensive Care. Published 28 November 2024. doi:10.
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