Perioperative medicine & outcomes

The association of the perioperative fluid balance and cardiopulmonary complications in emergency gastrointestinal surgery: exploration of a randomized trial

Perioper Med (Lond)Published Secondary analysis of the GAS-ART randomised trial

Primary resultResult — go to the resultOdds ratio 3.4 95% CI 1.5–7.6

Authors' conclusion

Following emergency surgery for gastrointestinal obstruction or perforation, a fluid balance < 2.0 L was associated with decreased risk of cardiopulmonary complications without increasing renal complications.

Study context

Population
Patients undergoing emergency surgery for gastrointestinal obstruction or perforation
Participants
303 patients
Comparison
Perioperative fluid balance high > 2 L or low < 0 L vs moderate 0-2 L
  • Low-FBn = 44
  • Moderate-FBn = 108reference
  • High-FBn = 151
Primary endpoint
Cardiopulmonary complications
Methodological detailspropensity adjusted logistic regression
  • Propensity adjusted logistic regression

Primary result

As reported in the abstract

Odds ratio

3.4

95% CI 1.5–7.6

P = 0.002

High-FB vs Moderate-FB
OR 3.4 (95% CI 1.5–7.6); P = 0.002

Further findings

Median, L

OutcomeLow-FBModerate-FBHigh-FB
Perioperative FB−0.9 (IQR −1.4–-0.6)0.9 (IQR 0.5–1.3)3.8 (IQR 2.7–5.3)

Original publication

The association of the perioperative fluid balance and cardiopulmonary complications in emergency gastrointestinal surgery: exploration of a randomized trial. Perioper Med (Lond). Published 26 April 2024. doi:10.1186/s13741-024-00390-y

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