Perioperative medicine & outcomes
Association of Peripheral Nerve Block with Postoperative Myocardial Injury in High-risk Cardiac Older Adults Undergoing Hip Fracture Surgery: A Two-center Retrospective Cohort Study
Main findingResult — go to the resultAdjusted odds ratio 0.60 95% CI 0.44–0.82Authors' conclusion
Single-injection PNB as an adjunct to general or neuraxial anesthesia was associated with a reduced risk of postoperative myocardial injury in high-risk cardiac older adults undergoing hip fracture surgery, possibly through mitigating the link between pain and myocardial injury.
Study context
- Population
- Patients ≥65 yr (high-risk cardiac older adults) undergoing hip fracture surgery during general or neuraxial anesthesia, 2012–2023included in final analysis
- Participants
- 1,467 patients
- Exposure
- Peripheral nerve block (PNB) vs non-PNB
- PNBn = 798
- non-PNBn = 669reference
- Outcome
- Postoperative myocardial injury (any postoperative cardiac troponin >99th percentile upper reference limit)
- Follow-up
- Index hospitalization
Methodological detailstwo-center, inverse probability of treatment weighting, multiple imputation, Missing data (24.3% of cases) imputed by multiple imputation
- Two-center
- Inverse probability of treatment weighting
- Multiple imputation
- Missing data (24.3% of cases) imputed by multiple imputation
Main finding
As reported in the abstract
Adjusted odds ratio
0.60
95% CI 0.44–0.82
P = 0.002
Events by group
PNB vs non-PNB
aOR 0.60 (95% CI 0.44–0.82); P = 0.002
Observational data: associations, not effects.
Original publication
Association of Peripheral Nerve Block with Postoperative Myocardial Injury in High-risk Cardiac Older Adults Undergoing Hip Fracture Surgery: A Two-center Retrospective Cohort Study. Anesthesiology. Published 29 December 2025. doi:10.
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