Perioperative medicine & outcomes
Anesthetic Technique and Perioperative Morbidity in Lower Extremity Amputation: A Retrospective Cohort Study
Authors' conclusion
In this high-risk LEA cohort, SA was associated with lower composite perioperative morbidity compared with GA, primarily reflecting respiratory and escalation-of-care outcomes.
Study context
- Population
- Adults undergoing nontraumatic, nonmalignant lower extremity amputation, single tertiary-care academic hospital in Pakistan, 2014–2024
- Participants
- 392 adults
- Exposure
- Spinal anesthesia (SA) or peripheral nerve block (PNB) vs general anesthesia (GA) as sole anesthetic technique
- GAn = 149reference
- SAn = 181
- PNBn = 62
- Outcome
- Composite perioperative morbidity:
- MACE
- CPR
- Unplanned intubation
- Unplanned ICU admission
- Prolonged mechanical ventilation
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Each group vs GAAdjusted odds ratio (95% CI)P value
SA
0.38(0.19–0.75)
P = 0.005PNBafter adjustment
0.44(0.18–1.07)
P = 0.069Observational data: associations, not effects.
Secondary outcomes
MACE, CPR and in-hospital mortality
- No significant difference across anesthetic groups
Composite morbidity, SA vs GA (propensity-score matched sensitivity analysis)
- Directionally consistent with the primary analysis
Original publication
Anesthetic Technique and Perioperative Morbidity in Lower Extremity Amputation: A Retrospective Cohort Study. J Cardiothorac Vasc Anesth. Published 7 August 2026. doi:10.
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