Perioperative medicine & outcomes
Association of Prophylactic Antibiotic Guideline Non-Adherence with Surgical Site Infections in Patients Receiving Perioperative Vancomycin: Results from a Multi-Institutional Combined National Surgical Quality Improvement Program (NSQIP) and Multicenter Perioperative Outcomes Group (MPOG) Registry
Authors' conclusion
Guideline adherent antibiotic choice (IDSA/SIS/SHEA metric) and time of vancomycin administration (IDSA/SIS/SHEA and SCIP metric) are associated with reduced odds of Surgical Site Infections in patients receiving perioperative vancomycin prophylaxis.
Study context
- Population
- Adults over 18 years undergoing non-cardiac procedures with skin incision who received vancomycin, 31 academic and community hospitals, 01/01/2014 to 08/31/2022
- Participants
- 5,542 participants · 31 hospitals
- Exposure
- Non-adherence vs adherence to Infectious Disease Society of America (IDSA)/Surgical Infection Society (SIS)/Society for Healthcare Epidemiology of America (SHEA) guideline antibiotic choice, dose or timing of vancomycin prophylaxis
- Non-adherent choicen = 705
- Non-adherent dosingn = 59
- Non-adherent timingn = 197
- Outcome
- NSQIP/MSQC-coded SSI
Methodological detailsregistry-based (MPOG, NSQIP, Michigan Surgical Quality Collaborative (MSQC)), hierarchical generalized linear mixed model
- Registry-based (MPOG, NSQIP, MSQC)
- Hierarchical generalized linear mixed model
Main finding
As reported in the abstract
SSI
Relative risk (95% CI)P value
Non-adherence to choice vs Adherence
1.64(1.17–2.31)
P = 0.004Non-adherence to timing vs Adherence
1.56(1.01–2.40)
P = 0.043- Incidence of SSI in the cohort
- 5.6%
Observational data: associations, not effects.
Original publication
Association of Prophylactic Antibiotic Guideline Non-Adherence with Surgical Site Infections in Patients Receiving Perioperative Vancomycin: Results from a Multi-Institutional Combined NSQIP and MPOG Registry. Ann Surg. Published 20 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →