Neuroanesthesia & neurocritical care
Associations of positive end-expiratory pressure (PEEP) with extubation failure and clinical outcomes in invasively ventilated patients with acute brain injury: A secondary analysis of the ENIO study
Primary result · Extubation failureResult — go to the resultOdds ratio 1.13 95 % CI 1.01–1.26Authors' conclusion
Extubating ABI patients at higher PEEP levels was associated with an increased risk of extubation failure and ICU mortality.
Study context
- Population
- Invasively ventilated patients with acute brain injury who received an extubation trial
- Participants
- 1,154 included patients
- Comparison
- Higher vs lower PEEP levels
- Primary endpoint
- Extubation failure and ICU mortality
Methodological detailspost-hoc analysis
- Post-hoc analysis
Primary result
Extubation failure · Days 1, 3 and 7 (median PEEP)
Odds ratio
1.13
95 % CI 1.01–1.26
P = 0.0294
Higher vs lower PEEP levels
OR 1.13 (95 % CI 1.01–1.26); P = 0.0294
As reported in the abstract
%
- Extubation failure, overall
- 21.2
- Intensive care unit (ICU) mortality, overall
- 3.7
Further findings
Extubation failure and ICU mortality · Time of extubation
| Estimate | P value | ||
|---|---|---|---|
| Higher PEEPExtubation failure | OR 1.13 (95 % CI 1.02–1.25) | P = 0.0218 | |
| Higher PEEPICU mortality | HR 1.38 (95 % CI 1.12–1.69) | P = 0.0026 | |
| 0.512Ratio (log scale) |
Sensitivity analyses adjusted for acute respiratory distress syndrome (ARDS)
- PEEP no longer significantly associated with outcomes; ARDS an independent predictor of extubation failure
Original publication
Associations of positive end-expiratory pressure (PEEP) with extubation failure and clinical outcomes in invasively ventilated patients with acute brain injury: A secondary analysis of the ENIO study. J Crit Care. Published 7 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →