Neuroanesthesia & neurocritical care
Lung-Protective Mechanical Ventilation in Patients with Severe Acute Brain Injury: A Multicenter Randomized Clinical Trial (PROLABI)
Primary result · Composite of death, ventilator dependency and ARDSResult — go to the resultRelative risk 1.35 95% CI 1.03–1.79Authors' conclusion
In patients with acute brain injury without ARDS, a lung-protective ventilatory strategy, as compared with a conventional strategy, did not reduce mortality, percentage of patients weaned from mechanical ventilation, or incidence of ARDS and was not beneficial in terms of neurological outcomes.
Study context
- Population
- Adults with acute brain injury
- Participants
- 190 adults
- Comparison
- Lung-protective vs conventional ventilatory strategy
- Primary endpoint
- Composite of:
- Death
- Ventilator dependency
- Acute respiratory distress syndrome (ARDS)
- Follow-up
- Day 28
Methodological detailsmulticentre, open-label
- Multicentre
- Open-label
Primary result
As reported in the abstract
28 days
Relative risk
1.35
95% CI 1.03–1.79
P = 0.025
By group
Lung-protective vs Conventional
RR 1.35 (95% CI 1.03–1.79); P = 0.025
Further findings
| Outcome | Lung-protective | Conventional | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| Mortality (composite component) | 28.9% | 15.1% | 1.91 (1.06–3.42) | P = 0.02 | |
| Ventilator dependency (composite component) | 42.3% | 27.9% | 1.52 (1.01–2.28) | P = 0.039 | |
| ARDS incidence (composite component) | 30.8% | 22.1% | 1.39 (0.85–2.27) | P = 0.179 | |
| 0.20.5125Relative risk (log scale) |
Original publication
Lung-Protective Mechanical Ventilation in Patients with Severe Acute Brain Injury: A Multicenter Randomized Clinical Trial (PROLABI). Am J Respir Crit Care Med. Published 1 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →