Attributable mortality due to nosocomial sepsis in Brazilian hospitals: a case–control study
Authors' conclusion
The impact of nosocomial sepsis on outcome is more pronounced in medical admissions and tends to increase over time. The results, however, are sensitive to sepsis definitions.
Study context
- Population
- Hospitalized patients in 37 hospitals in Brazil
- Participants
- 3,588 patients · 37 hospitals
- Comparison
- Nosocomial sepsis vs no nosocomial sepsis
- Outcome
- Nosocomial sepsis-attributable mortality fraction (AF), by inverse probability weighting with a generalized mixed model accounting for time-dependency of sepsis
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Average AF for sepsis mortality, by admission type
AF, medical admissions
0.076
95% CI 0.068–0.084
AF, elective surgical admissions
0.043
95% CI 0.032–0.055
AF, emergency surgeries
0.036
95% CI 0.017–0.055
Further findings
Events
| Outcome | Cases | Controls |
|---|---|---|
| Sepsis episodes | 311 | 77 |
- Sepsis episodes — Sepsis episodes in 388 patients
- 470
- Sepsis episodes — Pneumonia as most common source of infection
- 44.3%
Time-dependent AF by admission type · day 28
- Medical admissions: AF rose linearly, close to
- 0.12
- Elective surgery: AF plateaued earlier at
- 0.04
- Urgent surgery: AF plateaued earlier at
- 0.07
Alternative sepsis definitions
- Alternative sepsis definitions yield different estimates
Original publication
Attributable mortality due to nosocomial sepsis in Brazilian hospitals: a case–control study. Ann Intensive Care. Published 26 April 2023. doi:10.
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