Perioperative medicine & outcomes
Automated Computed Tomography (CT) Analysis of Body Composition as a Frailty Biomarker in Abdominal Surgery
Main finding · 30-day readmission or mortality (muscle quantity and quality score)Result — go to the resultRelative risk 0.61 95% CI 0.56–0.67Authors' conclusion
In this study, higher muscle quantity and quality scores were correlated with frailty and associated with 30-day readmission and postoperative mortality and morbidity, whereas body size and adipose tissue distribution scores were not correlated with patient frailty and had inconsistent associations with surgical outcomes.
Study context
- Population
- Adults undergoing abdominal surgery at 20 Kaiser Permanente Northern California medical centers, 2010–2020random sample
- Participants
- 48,444 adults
- Exposure
- Body composition scores from automated abdominal CT analysis
- Outcome
- All-cause 30-day postdischarge readmission or postoperative mortality
- Follow-up
- 30 days
Methodological detailsmulticentre, automated CT segmentation, principal component analysis
- Multicentre
- Automated CT segmentation
- Principal component analysis
Main finding
As reported in the abstract
30-day readmission or mortality (muscle quantity and quality score)
Relative risk
0.61
95% CI 0.56–0.67
Quartile 4 vs Quartile 1
RR 0.61 (95% CI 0.56–0.67)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | RR (95% CI) | |
|---|---|---|
| 30-day postoperative morbidity (muscle quantity and quality score) | 0.59 (0.52–0.67) | |
| 0.512Relative risk (log scale) |
- 30-day postoperative morbidity (muscle quantity and quality score): independent of sex, age, comorbidities, BMI, procedure characteristics, and the Hospital Frailty Risk Score (HFRS)
Correlation of muscle quantity and quality score with HFRS
- Inverse correlation, r
- −0.42
- 95% CI, −0.43 to −0.41
Body size and adiposity distribution scores after HFRS adjustment
- Attenuated and only associated with 30-day postoperative morbidity
Original publication
Automated CT Analysis of Body Composition as a Frailty Biomarker in Abdominal Surgery. JAMA Surg. Published 1 July 2024. doi:10.
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