Cardiac arrest & resuscitation
Baseline measurements of cellular respiration affect the response to thiamine treatment in post-arrest patients
Authors' conclusion
Thiamine supplementation was associated with reduced lactate in patients with preserved mitochondrial functional reserve.
Study context
- Population
- Post-cardiac arrest patients with baseline OCR measurements in peripheral blood mononuclear cells (PBMCs) (Seahorse XF Analyzer)baseline OCR measured
- Participants
- 74 patients
- Comparison
- Thiamine vs placebo, stratified by baseline PBMC oxygen consumption rates (above vs below cohort median)
- Thiaminen = 40
- Placebon = 34reference
- Primary endpoint
- Change in lactate
- Follow-up
- 24 h
Methodological detailsTHICA, THACA, subgroup analysis by baseline mitochondrial respiration
- THICA, THACA
- Subgroup analysis by baseline mitochondrial respiration
Primary result
As reported in the abstract
Lactate at 24 h, patients with maximal or spare respiration above the median (subgroups)
Thiamine vs PlaceboGeometric mean ratio (95% CI)P value
Maximal respiration above median
0.61(0.44–0.83)
P = 0.003Spare respiration above median
0.53(0.38–0.75)
P < 0.001Further findings
| Outcome | GMR (95% CI) | P value | |
|---|---|---|---|
| Lactate, overall cohort | 0.83 (0.64–1.09) | P = 0.19 | |
| 0.512Geometric mean ratio (log scale) |
Original publication
Baseline measurements of cellular respiration affect the response to thiamine treatment in post-arrest patients. Resuscitation. Published 25 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →