ICU sedation, delirium & recovery
Benzodiazepine and z-drug prescribing in critical care survivors and the risk of rehospitalisation or death due to falls/trauma and due to any cause: a retrospective matched cohort study using the UK Clinical Practice Research Datalink
Main finding · Falls/trauma-related eventsResult — go to the resultAdjusted hazard ratio 1.27 95% CI 0.76–2.14Authors' conclusion
Community benzodiazepine and z-drug prescribing was associated with increased risk of all-cause, but not falls/trauma-related, rehospitalisations and deaths in critical care survivors who had not been prescribed these before hospitalisation.
Study context
- Population
- Adult critical care survivors hospitalised in 2010 and 2018, UKmatched cohort
- Participants
- 28,678 survivors
- Exposure
- Community benzodiazepine/z-drug prescribing vs unexposed
- Benzodiazepines or z-drugsn = 4,844
- Unexposedn = 23,834reference
- Outcome
- Falls/trauma-related events; all-cause rehospitalisation or death
- Follow-up
- 30 days
Methodological detailsmultivariable stratified Cox regression, UK Clinical Practice Research Datalink linked datasets
- Multivariable stratified Cox regression
- UK Clinical Practice Research Datalink linked datasets
Main finding
Falls/trauma-related events
Adjusted hazard ratio
1.27
95% CI 0.76–2.14
Benzodiazepines or z-drugs vs Unexposed
aHR 1.27 (95% CI 0.76–2.14)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Falls/trauma-related events, treatment-naïve (subgroup) | 1.79 (0.61–5.26) | |
| All-cause rehospitalisation or death · 30 daysBenzodiazepines or z-drugs vs Unexposed · whole cohort | 1.24 (1.14–1.36) | |
| All-cause rehospitalisation or death · 30 daysBenzodiazepines or z-drugs vs Unexposed · treatment-naïve | 1.66 (1.49–1.86) | |
| All-cause rehospitalisation or death, excluding palliative care (sensitivity analysis) · 30 daysBenzodiazepines or z-drugs vs Unexposed · whole cohort | 1.08 (0.98–1.19) | |
| All-cause rehospitalisation or death, excluding palliative care (sensitivity analysis) · 30 daysBenzodiazepines or z-drugs vs Unexposed · treatment-naïve | 1.42 (1.25–1.62) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Original publication
Benzodiazepine and z-drug prescribing in critical care survivors and the risk of rehospitalisation or death due to falls/trauma and due to any cause: a retrospective matched cohort study using the UK Clinical Practice Research Datalink. Intensive Care Med. Published 7 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →