Cardiac arrest & resuscitation
Between-hospital variability in outcomes after cardiac arrest in a large clinical trial network
Authors' conclusion
This prospective, multicenter study suggests that the marked between-hospital variability in OHCA outcomes consistently observed in previous cohorts persists today.
Study context
- Population
- Adults screened for the ICECAP trial after resuscitation from OHCA at 69 hospitals, April 2020–March 2024, excluding those who died before admission, were awake on presentation, or had severe preexisting functional impairment or terminal illness
- Participants
- 8,603 adults · 69 hospitals
- Outcome
- Between-hospital variability in survival to discharge, overall and adjusted for patient factors
- Follow-up
- Hospital discharge
Methodological detailscohort study, Bayesian hierarchical regression, risk-adjusted
- Cohort study
- Bayesian hierarchical regression
- Risk-adjusted
Main finding
As reported in the abstract
Survival to discharge and between-hospital variability
Survived to discharge, n (%)
2192
25%
Median survival to discharge by site [IQR]
28%
IQR 24–32%
Median OR across sites, unadjusted
1.80 (1.72-1.91) (95% CrI)
Median OR across sites, adjusted for patient characteristics
1.90 (1.80-2.03) (95% CrI)
Observational data: associations, not effects.
Further findings
Site volume and temperature management practices vs risk-adjusted survival
- No relationship with risk-adjusted outcomes
Original publication
Between-hospital variability in outcomes after cardiac arrest in a large clinical trial network. Resuscitation. Published 12 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →