Respiratory failure & ventilation

Beyond recovery: long-term cardiovascular risks after severe COVID-19 requiring intensive care

Crit CarePublished Nationwide population-based matched cohort study

Main finding · ASCVDResult — go to the resultSubdistribution hazard ratio 1.42 95% CI 1.26–1.60

Authors' conclusion

Among ICU-treated survivors of severe COVID-19, the risk of ASCVD, heart failure, atrial fibrillation, and all-cause mortality was increased during three years of follow-up compared with the matched population-based controls, with associations strongest during the first year of follow-up [period-specific estimates are provided in the Supplementary].

Study context

Population
Adults with confirmed COVID-19 requiring mechanical ventilation in the intensive care unit (ICU), discharged alive, Swedenpropensity-matched
Participants
16,530 adults
Exposure
Cases vs Controls
  • Casesn = 3,350
  • Controlsn = 13,180reference
Outcome
Atherosclerotic cardiovascular disease (ASCVD) events occurring more than 30 days after ICU discharge
Follow-up
three-year follow-up
Methodological details1:4 propensity score matched, Swedish Intensive Care Registry
  • 1:4 propensity score matched
  • Swedish Intensive Care Registry

Main finding

ASCVD

Subdistribution hazard ratio

1.42

95% CI 1.26–1.60

Cases vs Controls
sHR 1.42 (95% CI 1.26–1.60)

As reported in the abstract

Observational data: associations, not effects.

Secondary outcomes

OutcomeEstimate
Hospitalization with AFsHR 1.85 (95% CI 1.64–2.10)
Hospitalization for HFsHR 1.81 (95% CI 1.57–2.09)
All-cause mortalityHR 1.48 (95% CI 1.26–1.74)

Original publication

Beyond recovery: long-term cardiovascular risks after severe COVID-19 requiring intensive care. Crit Care. Published 25 May 2026. doi:10.1186/s13054-026-06088-5

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