Cardiac arrest & resuscitation
Bicarbonate, calcium, and magnesium for in-hospital cardiac arrest – An instrumental variable analysis
Authors' conclusion
In this analysis, the results for bicarbonate, calcium, and magnesium were inconclusive due to wide confidence intervals and inconsistencies in estimates across instrumental variables.
Study context
- Population
- Adults with in-hospital cardiac arrest, Get With The Guidelines registry, January 2008–December 2021
- Participants
- 319,230 adults
- Exposure
- Bicarbonate, calcium or magnesium vs no drug
- Outcome
- Survival to hospital discharge
Methodological detailsinstrumental variable analysis, registry-based, instrumental variable approach
- Instrumental variable analysis
- Registry-based
- Instrumental variable approach
Main finding
As reported in the abstract
Survival to hospital discharge (instrument: drug use in previous cardiac arrest patient at hospital)
Each group vs no drugAbsolute difference, % (95% CI)
Bicarbonate
−14.2(−19.9 to −8.6)
Calcium
−3.0(−8.6 to 2.6)
Magnesium
10.7(−0.8 to 22.2)
Observational data: associations, not effects.
Further findings
Survival to hospital discharge (instrument: proportion of drug use within past year at hospital)
- Very wide CIs, results difficult to interpret
Drug administration
- Bicarbonate administered
- 58%
- Calcium administered
- 33%
- Magnesium administered
- 10%
Original publication
Bicarbonate, calcium, and magnesium for in-hospital cardiac arrest – An instrumental variable analysis. Resuscitation. Published 1 September 2023. doi:10.
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