Cardiac arrest & resuscitation
Pharmacological interventions for the acute treatment of hyperkalaemia: A systematic review and meta-analysis
Authors' conclusion
Evidence supports treatment with insulin in combination with glucose, inhaled or intravenous sal-butamol, or the combination. No evidence supporting a clinical effect of calcium or bicarbonate for hyperkalaemia was identified.
Study context
- Population
- Patients with hyperkalaemia, with and without cardiac arrest101 studies
- Comparison
- Acute pharmacological interventions for hyperkalaemia
- Outcome
- Potassium reduction, adults without cardiac arrest
Methodological detailsPRISMA, GRADE, randomized trials, non-randomized trials, observational studies and experimental animal studies
- PRISMA
- GRADE
- Randomized trials, non-randomized trials, observational studies and experimental animal studies
Pooled result
As reported in the abstract
Average potassium reduction with insulin + glucose, inhaled salbutamol, IV salbutamol in glucose, or a combination (very low to low certainty)
between 0.7 and 1.2 mmol/l
Further pooled results
Potassium reduction, neonatal and paediatric populations
- Average potassium reduction with inhaled and IV salbutamol (very low to low certainty)
- between 0.9 and 1.0 mmol/l
Calcium for hyperkalaemia
- No evidence of a clinical beneficial effect of calcium
Original publication
Pharmacological interventions for the acute treatment of hyperkalaemia: A systematic review and meta-analysis. Resuscitation. Published 4 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →