Cardiac arrest & resuscitation
Combination of Hydrogen Inhalation and Hypothermic Temperature Control After Out-of-Hospital Cardiac Arrest: A Post hoc Analysis of the Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During PostCardiac Arrest Care II Trial
Authors' conclusion
Hydrogen + TTM32-TTM34 was associated with improved neurologic outcomes after cardiogenic OHCA compared with TTM32-TTM34 monotherapy.
Study context
- Population
- Cardiogenic out-of-hospital cardiac arrest (OHCA) patients enrolled in the HYBRID II trial, 15 Japanese ICUswith outcome data
- Participants
- 72 patients
- Comparison
- Hydrogen mixed oxygen vs oxygen alone, under hypothermic target temperature management (TTM)
- Hydrogenn = 39
- Controln = 33reference
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Good neurologic outcomes under TTM32-TTM34 · 90-day
Estimate (95% CI)P value
Hydrogen vs Control
RR 1.81(1.05–3.66)
P < 0.05Hydrogen + TTM32-TTM34generalized estimating equations
aOR 16.10(1.88–138.17)
P = 0.01Further findings
TTM32-TTM34 implemented
P = 0.46
| Outcome | aHR for death (95% CI) | P value | |
|---|---|---|---|
| Survival, hydrogen + TTM32-TTM34 vs TTM32-TTM34 alone · 90-dayDid not improve survival | 0.22 (0.05–1.06) | P = 0.06 | |
| 0.050.21520AHR for death (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Combination of Hydrogen Inhalation and Hypothermic Temperature Control After Out-of-Hospital Cardiac Arrest: A Post hoc Analysis of the Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During PostCardiac Arrest Care II Trial. Crit Care Med. Published 12 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →