Cardiac arrest & resuscitation
Comparison of hypothermic and normothermic targeted temperature management in out-of-hospital cardiac arrest patients with acute coronary syndrome: a nationwide retrospective study
Authors' conclusion
In this nationwide, retrospective study using the JAAM-OHCA registry, we found no significant differences in 30-day favorable neurological outcome, 30-day survival, and adverse event incidences between hypothermic TTM (32-34°C) and normothermic TTM (35-36°C) in adult patients with OHCA due to ACS.
Study context
- Population
- Adults with OHCA due to acute coronary syndrome (ACS) who received targeted temperature management (TTM), Japanese Association for Acute Medicine Out-of-Hospital Cardiac Arrest (JAAM-OHCA) registry, June 2014–December 2020
- Participants
- 1,217 adults
- Exposure
- Hypothermic TTM vs normothermic TTM
- Hypothermic TTMn = 848
- Normothermic TTMn = 369reference
- Outcome
- Favorable neurological outcome (Cerebral Performance Category (CPC) 1-2)
- Follow-up
- 30 days
Methodological detailsnationwide registry, multivariable logistic regression, inverse probability weighting
- Nationwide registry
- Multivariable logistic regression
- Inverse probability weighting
Main finding
As reported in the abstract
30-day favourable neurological outcome (CPC 1-2)
Observational data: associations, not effects.
Secondary outcomes
30-day survival
- No significant difference
Safety
Adverse event incidence
- No significant difference
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Comparison of hypothermic and normothermic targeted temperature management in out-of-hospital cardiac arrest patients with acute coronary syndrome: a nationwide retrospective study. Crit Care. Published 6 January 2025. doi:10.
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