Cardiac arrest & resuscitation
Hypothermia versus normothermia after out-of-hospital cardiac arrest; the effect on post-intervention serum concentrations of sedatives and analgesics and time to awakening
Authors' conclusion
This study of OHCA patients treated at normothermia versus hypothermia found no significant differences in dosing or concentration of sedatives or analgesic drugs in blood samples drawn at the end of the TTM intervention, or at end of protocolized fever prevention, nor the time to awakening.
Study context
- Population
- Out-of-hospital cardiac arrest (OHCA) patients alive at 40 hours who received the targeted temperature management (TTM) intervention per protocol, under mandatory deep sedation
- Participants
- 71 participants
- Comparison
- Hypothermia vs normothermia after OHCA
- Hypothermian = 33
- Normothermian = 38reference
- Primary endpoint
- Cumulative doses and serum concentrations of sedatives and analgesics, and time to awakening
- Follow-up
- End of TTM and end of protocolized fever prevention (72 hours)
Methodological details3 centres in Sweden
- 3 centres in Sweden
Primary result
As reported in the abstract
Cumulative doses and concentrations of sedatives/analgesics · any timepoint
- No differences between groups in cumulative doses or concentrations of sedatives/analgesics at any timepoint
Further findings
Time until awakening
P = 0.09
Original publication
Hypothermia versus normothermia after out-of-hospital cardiac arrest; the effect on post-intervention serum concentrations of sedatives and analgesics and time to awakening. Resuscitation. Published 11 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →